Modeling human microglia

Most in vitro research on microglial cells is done using mouse-derived cell lines even though murine microglial cells differ from their human counterparts. To address this limitation, we seek to establish human neuronal and microglial cell lines. The aim is to develop human in vitro model systems and to explore their potential in cell regenerative therapies. Our human neuronal and microglial cell lines can also shed light on the interplay between the immune system and the nervous system in the development of brain disorders.