Physical activity seems to be a promising preventive strategy to reduce the risk of developing certain brain disorders. Still, how exercise affects molecular processes in the brain is largely unknown.

To determine the molecular effects of exercise in the brain, we use mouse models of different brain disorders, including Alzheimer's disease, vascular dementia, and brain ischemia. We study how running exercise affects the development of these disorders at different levels, from the molecular processes and cellular functions to animal behavior. Our main focus is to elucidate how exercise interventions affect neuroinflammation and how this can affect disease progression.