The exchange of cerebrospinal fluid (CSF) seems to be crucial for the clearance of waste products from the brain. Previous research shows that impaired CSF clearance is associated with neurodegenerative diseases. After systemic injections with LPS, the mice displayed elevations of microglial Iba-1 together with reductions of perivascular CSF tracer distribution. Our observations add to the knowledge of how systemic inflammation might affect brain clearance.

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