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Microglia govern the brain and protect it, but in the wrong context, they can also cause harm. Their activity needs to be well timed and balanced, or things go off course. When they get stuck in the wrong gear, microglia can drive neurodegeneration. Scientists in the Neuroinflammation research group believe that by targeting a protein called Galectin-3, microglial states can be tuned.
"We previously identified Galectin-3 to be a detrimental factor in the context of chronic neuroinflammation, especially in Alzheimer’s, Parkinson’s and Frontotemporal dementia; but we did not know whether the effects were driven by the protein found in extracellular or intracellular spaces," described first author Lluís Camprubí Ferrer.
This study highlights Galectin-3 as a potential therapeutic target for tuning microglial function.
Read the publication here.
